The Role of Genetics in Barrett's Esophagus Development
Barrett's esophagus is a condition in which the tissue lining the esophagus undergoes a change, primarily due to prolonged gastroesophageal reflux disease (GERD). This transformation involves the replacement of the normal squamous epithelium with columnar epithelium, creating an environment conducive to the development of esophageal adenocarcinoma, a more aggressive form of cancer. While the link between GERD and Barrett's esophagus is well-established, recent research has shed light on the intricate role that genetics plays in the development and progression of this condition. Genetic Predisposition and Susceptibility Family history often provides vital insights into the role of genetics in the development of various diseases. In the case of Barrett's esophagus, familial clustering and heritability have been observed, suggesting a genetic predisposition. Multiple studies have shown an increased risk of Barrett's esophagus among first-degree relatives of affected in...